Anesthesia and Analgesia – Roundtable Discussion
Panel Discussion - In-person/live
Speakers: Amy Martunas, Justin HartmanSurgical Anesthetic Preparation in the Juvenile NHP
Symposia - In-person/live
Speaker: Justin HartmanDue to the high demand for NHP’s as research models, and the disruptions that Covid 19 created amongst the suppliers of NHP’s, we have been dealing with a downward trend in the range of body weights in our surgical animals. 4 to 5 years ago, the average size of an NHP that we would be performing a surgical procedure on was around 3.5 kgs. Now, we are routinely performing major surgical procedures on animals from 1.5 kgs to 2.5 kgs. These smaller animals are technically juveniles and they can have different anesthetic needs. This change in size of the animal can […]
Pharmacokinetics of Methadone in Cynomolgus Macaques
Symposia - In-person/live
Speaker: Amy MartunasIntroduction: Methadone, a synthetic opioid has gained popularity as an analgesic for surgical procedures as it provides a longer effective duration compared to common opioids for moderate to severe pain. Pharmacokinetic (PK) data in dogs and humans demonstrate therapeutic duration for 12-14 hours. This study investigates the pharmacokinetics of methadone at 2 dose levels in Cynomolgus Macaques for use as extended duration opioid for surgical procedures involving moderate to severe pain post-operatively. Methods: 8 Mauritius origin Cynomolgus Macaques were administered 0.2mg/kg and 0.5 mg/kg methadone hydrochloride intramuscularly (IM) and plasma and urine collected at predetermined time points and analyzed. Average mean […]
Time: 10:30 am
Duration: 30 minutes
Topics: analgesia, NHP, pharmacokinetics