Cerebral Oxygenation Monitoring in Rats Under Isoflurane Anesthesia


Introduction: Although monitoring of vital signs in small lab animals is critical to successful anesthetic outcomes, reliable measurement of the vital signs is challenging due to their size. To this end, we are developing a miniaturized optical imaging device based on the Near Infrared Spectroscopy (NIRS) technique for noninvasive measurement of the brain and peripheral tissue oxygenation and perfusion. Our goal is to develop a device to support safe and reliable anesthesia monitoring in small lab animals to improve animal welfare, ensure successful outcomes, and create reproducible research, which will ultimately aide in better knowledge of the living systems to enhance [...]