Evaluation of an African Green Monkey Model of Transient Ischemia


Speaker - Kimicia Isaac, St. Kitts Biomedical Research Foundation / Virscio, Inc.   The NIH estimates 800,000 Americans suffer strokes yearly, with significant mortality, long-term disability, and substantial unmet medical need. The lack of translation from small animal models to clinical efficacy has slowed therapeutic development. Nonhuman primates (NHP) share anatomy and physiology with humans important to the clinical pathophysiology of stroke and truly predictive preclinical modeling. An model of transient ischemia is described in adult male African green monkeys (Chlorocebus sabaeus) that promises to enable more robust evaluation of stroke therapeutics. Methods: 11 monkeys received a 180 min occlusion of [...]