Auditory related health conditions have warranted the development of new treatments and drugs including, for example, gene therapy focusing on restoring the sensory receptors of the auditory and vestibular systems known as hair cells. However, accessing and treating the cochlea containing these hair cells offers a formidable surgical challenge. This presentation will introduce anatomical features, landmarks, and dosing techniques for the cochlea. Surgical hints are shared but also pitfalls that may be encountered when developing and performing these dosing procedures are also discussed.
Introduction: Methadone, a synthetic opioid has gained popularity as an analgesic for surgical procedures as it provides a longer effective duration compared to common opioids for moderate to severe pain. Pharmacokinetic (PK) data in dogs and humans demonstrate therapeutic duration for 12-14 hours. This study investigates the pharmacokinetics of methadone at 2 dose levels in Cynomolgus Macaques for use as extended duration opioid for surgical procedures involving moderate to severe pain post-operatively. Methods: 8 Mauritius origin Cynomolgus Macaques were administered 0.2mg/kg and 0.5 mg/kg methadone hydrochloride intramuscularly (IM) and plasma and urine collected at predetermined time points and analyzed. Average mean [...]