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Time-Dependent Vascular Dysfunction in Sepsis: Insights from an Ex Vivo Porcine Saphenous Vein Model
Date: Friday, September 19, 2025
Time: 10:00 am
Presenter: Nubia Silva, University of Minnesota Background: To model and characterize time-dependent vascular dysfunction induced by sepsis in an ex vivo porcine vein system. Introduction: Sepsis is clinical syndrome driven by an overwhelming host response to infection, often progressing to circulatory failure and organ dysfunction. The vascular response to sepsis is characterized by vasoplegia—a state where blood vessels lose their ability to constrict, resulting in persistently low blood pressure resistant to usual therapies. Understanding how infection transitions to vasoplegia, particularly through vascular nitric oxide (NO) signaling, is essential for developing new therapies. We modeled these vascular changes ex vivo using porcine saphenous [...]
Time: 10:00 am
Presenter: Nubia Silva, University of Minnesota Background: To model and characterize time-dependent vascular dysfunction induced by sepsis in an ex vivo porcine vein system. Introduction: Sepsis is clinical syndrome driven by an overwhelming host response to infection, often progressing to circulatory failure and organ dysfunction. The vascular response to sepsis is characterized by vasoplegia—a state where blood vessels lose their ability to constrict, resulting in persistently low blood pressure resistant to usual therapies. Understanding how infection transitions to vasoplegia, particularly through vascular nitric oxide (NO) signaling, is essential for developing new therapies. We modeled these vascular changes ex vivo using porcine saphenous [...]