Intrathecal Dosing – Boldly Going Where Few Molecules Have Gone Before
Christine Siebert2024-03-18T04:28:35-05:00Scott Adrian, Charles River Laboratories, and Gayle Nugent, Charles River Laboratories Ever since 1898, when August Bier injected six patients and himself with cocaine into their intrathecal (IT) spaces, this method of administration has been explored.[1] Predominantly and historically used to deliver analgesia for chronic pain, many drugs have been utilized, including opioids, local anesthetics, calcium channel blockers, and alpha-2-agonists. But only three drugs, i.e., morphine, ziconotide, and baclofen are currently FDA approved for IT administration which continues to make this route a popular focus for targeted delivery of a variety of molecules for a variety of indications.[2] The advantages of intrathecal [...]
