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NHP

Novel Techniques for Wound Healing – Intact Fish Skin Grafts in the NHP

2022-09-27T11:18:29-05:00

This presentation will review the phases of wound healing, physiologic steps to achieve proper healing, the application of the graft as a wound dressing and the use of antimicrobial hydrogel, Manuka honey and foam dressing in combination with the graft as well as examples of wounds, difficulties encountered, successes achieved and summary of histological examination of tissues biopsied during this process. 

Novel Techniques for Wound Healing – Intact Fish Skin Grafts in the NHP2022-09-27T11:18:29-05:00

Technical Insights for Cochlear Administration in the NHP

2022-09-27T10:16:22-05:00

Auditory related health conditions have warranted the development of new treatments and drugs including, for example, gene therapy focusing on restoring the sensory receptors of the auditory and vestibular systems known as hair cells. However, accessing and treating the cochlea containing these hair cells offers a formidable surgical challenge. This presentation will introduce anatomical features, landmarks, and dosing techniques for the cochlea. Surgical hints are shared but also pitfalls that may be encountered when developing and performing these dosing procedures are also discussed.

Technical Insights for Cochlear Administration in the NHP2022-09-27T10:16:22-05:00

Minimally Invasive Lumber Intrathecal Port Implant in the NHP

2022-09-27T10:16:22-05:00

Lumbar intrathecal access port implantation for Cerebrospinal fluid (CSF) collection and/or intrathecal infusion in the non-human primate is being requested more frequently in the Safety Assessment world of biomedical research. Historically, performing a hemi-laminectomy to visualize and access the spinal dura for catheter cannulation has been the gold standard for the placement of these access catheters. There is an alternative. A minimally invasive technique using a Tuohy needle to access the intrathecal space and the advancing of an access catheter through this needle into the IT space with the need to perform a hemi-laminectomy, has proven to be an advantageous technique [...]

Minimally Invasive Lumber Intrathecal Port Implant in the NHP2022-09-27T10:16:22-05:00

Pharmacokinetics of Methadone in Cynomolgus Macaques

2022-09-27T11:18:00-05:00

Introduction: Methadone, a synthetic opioid has gained popularity as an analgesic for surgical procedures as it provides a longer effective duration compared to common opioids for moderate to severe pain. Pharmacokinetic (PK) data in dogs and humans demonstrate therapeutic duration for 12-14 hours. This study investigates the pharmacokinetics of methadone at 2 dose levels in Cynomolgus Macaques for use as extended duration opioid for surgical procedures involving moderate to severe pain post-operatively. Methods: 8 Mauritius origin Cynomolgus Macaques were administered 0.2mg/kg and 0.5 mg/kg methadone hydrochloride intramuscularly (IM) and plasma and urine collected at predetermined time points and analyzed. Average mean [...]

Pharmacokinetics of Methadone in Cynomolgus Macaques2022-09-27T11:18:00-05:00

Surgical Anesthetic Preparation in the Juvenile NHP

2022-09-27T10:16:23-05:00

Due to the high demand for NHP’s as research models, and the disruptions that Covid 19 created amongst the suppliers of NHP’s, we have been dealing with a downward trend in the range of body weights in our surgical animals. 4 to 5 years ago, the average size of an NHP that we would be performing a surgical procedure on was around 3.5 kgs. Now, we are routinely performing major surgical procedures on animals from 1.5 kgs to 2.5 kgs. These smaller animals are technically juveniles and they can have different anesthetic needs. This change in size of the animal can [...]

Surgical Anesthetic Preparation in the Juvenile NHP2022-09-27T10:16:23-05:00

Liver Regeneration Model in Cynomolgus Monkeys

2022-09-23T14:56:53-05:00

Introduction: About 41,260 new cases (28,600 in men and 12,660 in women) over liver cancer will be diagnosed in 2022 according to the American Cancer Society website. A model resecting approximately 60% of the liver by weight in cynomolgus monkeys is valuable in evaluating potential therapies that encourage natural regrowth of the liver post resection in human patients. Methods: Spanning three separate studies, a laparotomy was performed on a total of 26 animals, resecting approximately 60% of the total liver volume (by weight) of each animal’s liver. Liver volume was calculated based on historical organ (liver) weights measured at necropsy, determined [...]

Liver Regeneration Model in Cynomolgus Monkeys2022-09-23T14:56:53-05:00
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