Unbreak My Heart – The Reality of the Future? Regenerative Cardiovascular Research with Focus on Minipig Model
Symposia - In-person/live
Speaker – Nina Krutrök AstraZeneca After myocardial infarction (MI) patients lose up to 1 billion cardiomyocytes. The inability of the injured mammalian heart to regenerate the loss of contractile myocardial tissue leads to ischemic heart failure (HF). Despite major advances in the treatment of HF, the root cause of impairment is still unaddressed. Human Ventricular Progenitor cells (HVPs) engraft, differentiate into cardiomyocytes, and prevent disease progression after -MI-in the murine and porcine heart.1, 2 In our research we aim to study the effect of HVPs as a new modality in a post-MI pig model. Methods: Myocardial infarction was induced using […]
Time: 10:00 am
Duration: 30 minutes
Topics: cardiovascular, porcine, swine
Automated Blood Sampling in a Telemetry Cardiovascular Dog Colony
Symposia - In-person/live
Speaker – Amanda Wilsey Abbvie Implementation of Automated Blood Sampling (ABS) allows for uninterrupted cardiovascular data collection with simultaneous blood collection throughout a telemetry dog preclinical study. This reduction shortens study timelines, minimizes CV data artifacts, and considerably reduces compound synthesis and the associated costs. Methods: A colony of telemetry instrumented male beagle dogs were implanted and maintained in-house for non-GLP preclinical cardiovascular safety studies. Evaluation of the ABS telemetry dog cardiovascular model; highlighting the benefits and downfalls of the last seven years since implementing Automated Blood Sampling. Results: Since 2016, telemetry dogs implanted with transmitters and vascular access ports […]
Time: 10:30 am
Duration: 30 minutes
Topics: blood flow, cardiovascular, non-traditional species, surgical technique, telemetry