Automated Blood Sampling in a Telemetry Cardiovascular Dog Colony

Completed
4806Surgical Research – Leading the Way to Improve Patient Outcomes

Date: Wednesday, October 11, 2023
Time: 10:30 am CT
Duration: 30 Minutes
Room: Cumberland Ballroom, Salon ABCD

Speaker – Amanda Wilsey
Abbvie

 

Implementation of Automated Blood Sampling (ABS) allows for uninterrupted cardiovascular data collection with simultaneous blood collection throughout a telemetry dog preclinical study. This reduction shortens study timelines, minimizes CV data artifacts, and considerably reduces compound synthesis and the associated costs.

Methods:

A colony of telemetry instrumented male beagle dogs were implanted and maintained in-house for non-GLP preclinical cardiovascular safety studies. Evaluation of the ABS telemetry dog cardiovascular model; highlighting the benefits and downfalls of the last seven years since implementing Automated Blood Sampling.

Results: 

Since 2016, telemetry dogs implanted with transmitters and vascular access ports were used on cardiovascular ABS studies approximately 5 times annually, with an average service life of 2 years. With the high success rate of blood sample collections utilizing ABS during cardiovascular studies, we have expanded our telemetry colony to meet our study demands, which now account for 88% of all the in-house telemetry studies. Port and needle placement while on study, have been found to be the most challenging detail of this dog model.

Conclusion: 

Combining telemetry and ABS has enhanced pharmacokinetic/pharmacodynamic (PK/PD) understanding of drug-induced hemodynamic and electrocardiographic effects of discovery compounds in conscious beagles. The significant impact of high-quality cardiovascular data with simultaneous automated blood sampling has allowed for quicker determination of compound selection. The combination of automated blood sampling in the telemetry cardiovascular dog model reduces the number of dogs used, shortens study timelines, minimizes CV data artifacts, and considerably reduces compound synthesis and the associated costs. A significant reduction in stress from animal handling caused by multiple venipunctures allows for a positive 3R’s impact.

 

Additional Authors: B. Bird, Y. Koshman, G. Jasiek, O. Antic, C. M. Foley

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