Introduction: Industry has seen a shift in the use of genetically modified mice for the evaluation of cardiac performance and function. There is significant interest in developing novel therapies to treat heart failure and measuring the effectiveness of compounds. Many models exist in larger species however, there are limited translational models for mice. To evaluate compounds in mice, often large animal models are scaled down to be utilized in studies. In this presentation we will discuss the development of a murine model of left ventricular pressure cannulation (LVP). Currently, echocardiography is routinely used to assess disease progression in rodent models of [...]
Introduction: Routine cardiac catheterization for angioplasty and stenting has created a large population of patients with cardiac damage and subsequent long-term heart failure. Cardiac therapies are often administered directly to the heart by methods such as coronary sinus retrograde infusion. Understanding the differences in human and swine coronary sinus anatomy is crucial in preclinical safety studies, particularly for biodistribution evaluation. Contrast/ Dye studies aid in determining coronary sinus anatomy and catheter placement in the heart. Methods: Under general anesthesia, 9f or greater sheath was placed via jugular vein cutdown on three Landrace/ Duroc and two Yucatan swine. Using fluoroscopic guidance, a [...]
The use of large animal models in preclinical studies has provided invaluable data for evaluating the safety and efficacy of new therapies and devices and has facilitated the development and clinical application of cardiovascular innovations. With an increasingly valuable role, the implementation of large animal models has expanded, serving to bridge the translation of physiologic and economic aspects of animal research to the successful treatment of human heart failure. In this study, we report normal hemodynamic values, including aortic and pulmonary blood flow, in a bovine model at rest and during exercise after a control procedure.