Annual Meeting Agenda 2023

Automated Blood Sampling in a Telemetry Cardiovascular Dog Colony

Symposia - In-person/live

Speaker – Amanda Wilsey Abbvie   Implementation of Automated Blood Sampling (ABS) allows for uninterrupted cardiovascular data collection with simultaneous blood collection throughout a telemetry dog preclinical study. This reduction shortens study timelines, minimizes CV data artifacts, and considerably reduces compound synthesis and the associated costs. Methods: A colony of telemetry instrumented male beagle dogs were implanted and maintained in-house for non-GLP preclinical cardiovascular safety studies. Evaluation of the ABS telemetry dog cardiovascular model; highlighting the benefits and downfalls of the last seven years since implementing Automated Blood Sampling. Results:  Since 2016, telemetry dogs implanted with transmitters and vascular access ports […]

Evaluation of an African Green Monkey Model of Transient Ischemia

Symposia - In-person/live

Speaker – Kimicia Isaac, St. Kitts Biomedical Research Foundation / Virscio, Inc.   The NIH estimates 800,000 Americans suffer strokes yearly, with significant mortality, long-term disability, and substantial unmet medical need. The lack of translation from small animal models to clinical efficacy has slowed therapeutic development. Nonhuman primates (NHP) share anatomy and physiology with humans important to the clinical pathophysiology of stroke and truly predictive preclinical modeling. An model of transient ischemia is described in adult male African green monkeys (Chlorocebus sabaeus) that promises to enable more robust evaluation of stroke therapeutics. Methods: 11 monkeys received a 180 min occlusion of […]

The Sheep as a Model for Assessing Long Term Functional Patency and Maintenance of Arteriovenous Grafts

Symposia - In-person/live

Speaker – John Carney University of Minnesota   Patients with end stage renal disease often require vascular grafts to create arteriovenous (AV) shunts for hemodialysis access. However, graft complications frequently occur resulting in loss of functional patency and need for subsequent interventions. Although sheep have been used to evaluate preclinical graft safety, research lacks regarding use for prolonged graft maintenance and postoperative interventions. We sought to validate the sheep model in evaluating chronic AV graft patency and salvage techniques using clinically established approaches. Methods: Methods: Three (n = 3) adult sheep weighing 88 ± 21kg and 14 ± 1 months old […]

Anesthetic and Surgical Considerations for Liver Bleeding Assessment Models – Part I

Symposia - In-person/live

Speaker – Stephanie Vaughan Labcorp Early Development

Anesthetic and Surgical Considerations for Liver Bleeding Assessment Models – Part II

Symposia - In-person/live

Speaker – Stephanie Vaughan Labcorp Early Development