Annual Meeting Agenda 2023

Evaluation of an African Green Monkey Model of Transient Ischemia

Symposia - In-person/live

Speaker – Kimicia Isaac, St. Kitts Biomedical Research Foundation / Virscio, Inc.   The NIH estimates 800,000 Americans suffer strokes yearly, with significant mortality, long-term disability, and substantial unmet medical need. The lack of translation from small animal models to clinical efficacy has slowed therapeutic development. Nonhuman primates (NHP) share anatomy and physiology with humans important to the clinical pathophysiology of stroke and truly predictive preclinical modeling. An model of transient ischemia is described in adult male African green monkeys (Chlorocebus sabaeus) that promises to enable more robust evaluation of stroke therapeutics. Methods: 11 monkeys received a 180 min occlusion of […]

Practical Approach to Pain Management for Nonhuman Primates: Enhancing Welfare and Research Outcomes

Symposia - In-person/live

Speaker – Jan Bernal Amgen   Pain management is a critical component of responsible animal research and care, particularly in the context of nonhuman primates (NHPs) utilized in biomedical and behavioral studies. This presentation aims to provide a comprehensive overview of practical pain management strategies for NHPs, with a focus on enhancing their welfare while optimizing research outcomes. The presentation will begin by defining pain and classifications of pain. It will emphasize the pain pathways and the multimodal approaches effective at each of the pain pathways, encompassing a wide range of medication and procedural options to modulate pain.  Attendees will gain […]

Curious George Goes to The Podium

Panel Discussion - In-person/live

Nose Cone vs Intubated Ventilation During Open Chest Surgery in Rats – Nina Krutrök, AstraZeneca The aim of this study was to investigate if nose cone ventilation is comparable to endotracheal intubation. The latter is the most common approach for air delivery to rats undergoing open chest surgery for cardiovascular research during for example induction of myocardial infarction or epicardial injections. This method of air delivery is technically challenging leading to prolonged procedures and increased risk of endotracheal complications such as laryngeal damage and laryngeal edema, oral pharyngeal and/or tracheal laceration due to multiple intubation attempts. Nose cone ventilation is a […]