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Liver Regeneration Model in Cynomolgus Monkeys
Date: Thursday, September 15, 2022
Time: 10:30 am
Introduction: About 41,260 new cases (28,600 in men and 12,660 in women) over liver cancer will be diagnosed in 2022 according to the American Cancer Society website. A model resecting approximately 60% of the liver by weight in cynomolgus monkeys is valuable in evaluating potential therapies that encourage natural regrowth of the liver post resection in human patients. Methods: Spanning three separate studies, a laparotomy was performed on a total of 26 animals, resecting approximately 60% of the total liver volume (by weight) of each animal’s liver. Liver volume was calculated based on historical organ (liver) weights measured at necropsy, determined […]
Time: 10:30 am
Introduction: About 41,260 new cases (28,600 in men and 12,660 in women) over liver cancer will be diagnosed in 2022 according to the American Cancer Society website. A model resecting approximately 60% of the liver by weight in cynomolgus monkeys is valuable in evaluating potential therapies that encourage natural regrowth of the liver post resection in human patients. Methods: Spanning three separate studies, a laparotomy was performed on a total of 26 animals, resecting approximately 60% of the total liver volume (by weight) of each animal’s liver. Liver volume was calculated based on historical organ (liver) weights measured at necropsy, determined […]
Coronary Sinus Dosing in Swine, Anatomical Considerations in Comparison to Human Anatomy
Date: Thursday, September 15, 2022
Time: 1:30 pm
Introduction: Routine cardiac catheterization for angioplasty and stenting has created a large population of patients with cardiac damage and subsequent long-term heart failure. Cardiac therapies are often administered directly to the heart by methods such as coronary sinus retrograde infusion. Understanding the differences in human and swine coronary sinus anatomy is crucial in preclinical safety studies, particularly for biodistribution evaluation. Contrast/ Dye studies aid in determining coronary sinus anatomy and catheter placement in the heart. Methods: Under general anesthesia, 9f or greater sheath was placed via jugular vein cutdown on three Landrace/ Duroc and two Yucatan swine. Using fluoroscopic guidance, a […]
Time: 1:30 pm
Introduction: Routine cardiac catheterization for angioplasty and stenting has created a large population of patients with cardiac damage and subsequent long-term heart failure. Cardiac therapies are often administered directly to the heart by methods such as coronary sinus retrograde infusion. Understanding the differences in human and swine coronary sinus anatomy is crucial in preclinical safety studies, particularly for biodistribution evaluation. Contrast/ Dye studies aid in determining coronary sinus anatomy and catheter placement in the heart. Methods: Under general anesthesia, 9f or greater sheath was placed via jugular vein cutdown on three Landrace/ Duroc and two Yucatan swine. Using fluoroscopic guidance, a […]