Afternoon Wet Lab – Vanderbilt University
andyh2024-03-18T04:28:34-05:00Intermediate swine procedures and rat microsurgery and catheterization techniques
Anesthetic and Surgical Considerations for Liver Bleeding Assessment Models – Part II
Sydney Mensen2024-03-18T04:28:34-05:00Speaker - Stephanie Vaughan Labcorp Early Development
Surgical Research – Leading the Way to Improve Patient Outcomes
Hayleigh Culliton2024-03-18T04:28:34-05:00Keynote Speaker – Dr. Jose A. Diaz Directory, Division of Surgical Research, Vanderbilt University Nashville, TN
Anesthetic and Surgical Considerations for Liver Bleeding Assessment Models – Part I
Sydney Mensen2024-03-18T04:28:34-05:00Speaker - Stephanie Vaughan Labcorp Early Development
Curious George Goes to The Podium
Sydney Mensen2024-03-18T04:28:35-05:00Nose Cone vs Intubated Ventilation During Open Chest Surgery in Rats – Nina Krutrök, AstraZeneca The aim of this study was to investigate if nose cone ventilation is comparable to endotracheal intubation. The latter is the most common approach for air delivery to rats undergoing open chest surgery for cardiovascular research during for example induction of myocardial infarction or epicardial injections. This method of air delivery is technically challenging leading to prolonged procedures and increased risk of endotracheal complications such as laryngeal damage and laryngeal edema, oral pharyngeal and/or tracheal laceration due to multiple intubation attempts. Nose cone ventilation is a [...]
The Vital Role of Capnography in Surgical Research: Enhancing Patient Care and Surgical Outcomes
Sydney Mensen2024-03-18T04:28:35-05:00Speakers: Jan Bernal Amgen Amy Martunas Vertex Capnography has emerged as an indispensable tool in veterinary medicine, revolutionizing the way we monitor and manage patients during various surgical scenarios. This presentation is dedicated to shedding light on the fundamental principles, practical applications, and clinical benefits of capnography in veterinary practice. The presentation will commence by introducing the basic principles of capnography, elucidating the physiological underpinnings of carbon dioxide (CO2) measurement, and its significance in assessing both ventilatory and circulatory aspects of patient health. Attendees will gain insights into the mechanics of capnography, including the technology behind mainstream and side stream [...]
Practical Approach to Pain Management for Nonhuman Primates: Enhancing Welfare and Research Outcomes
Sydney Mensen2024-03-18T04:28:35-05:00Speaker - Jan Bernal Amgen Pain management is a critical component of responsible animal research and care, particularly in the context of nonhuman primates (NHPs) utilized in biomedical and behavioral studies. This presentation aims to provide a comprehensive overview of practical pain management strategies for NHPs, with a focus on enhancing their welfare while optimizing research outcomes. The presentation will begin by defining pain and classifications of pain. It will emphasize the pain pathways and the multimodal approaches effective at each of the pain pathways, encompassing a wide range of medication and procedural options to modulate pain. Attendees will gain [...]
Evaluation of an African Green Monkey Model of Transient Ischemia
Sydney Mensen2024-03-18T04:28:35-05:00Speaker - Kimicia Isaac, St. Kitts Biomedical Research Foundation / Virscio, Inc. The NIH estimates 800,000 Americans suffer strokes yearly, with significant mortality, long-term disability, and substantial unmet medical need. The lack of translation from small animal models to clinical efficacy has slowed therapeutic development. Nonhuman primates (NHP) share anatomy and physiology with humans important to the clinical pathophysiology of stroke and truly predictive preclinical modeling. An model of transient ischemia is described in adult male African green monkeys (Chlorocebus sabaeus) that promises to enable more robust evaluation of stroke therapeutics. Methods: 11 monkeys received a 180 min occlusion of [...]
Tips and Tricks on Surgeon and Animal Preparation-Aseptic Technique
Hayleigh Culliton2024-03-18T04:28:36-05:00Darcy Gagne, BD Most of us know the reasons for and how to prepare our surgeon and our patients for aseptic surgery without “issues”. Occasionally the various steps can become so routine that we may become lackadaisical with some of the techniques; subsequently, problems may arise without notice. Surgeon and animal preparation should be undertaken with the utmost care and attention to detail; refreshing these concepts is important. Materials & Methods: Too often we get in the groove of how we do things without considering the importance of surgeon and patient pre-op preparation, as well as intra- and post-operative care. [...]
Automated Blood Sampling in a Telemetry Cardiovascular Dog Colony
Sydney Mensen2024-03-18T04:28:36-05:00Speaker - Amanda Wilsey Abbvie Implementation of Automated Blood Sampling (ABS) allows for uninterrupted cardiovascular data collection with simultaneous blood collection throughout a telemetry dog preclinical study. This reduction shortens study timelines, minimizes CV data artifacts, and considerably reduces compound synthesis and the associated costs. Methods: A colony of telemetry instrumented male beagle dogs were implanted and maintained in-house for non-GLP preclinical cardiovascular safety studies. Evaluation of the ABS telemetry dog cardiovascular model; highlighting the benefits and downfalls of the last seven years since implementing Automated Blood Sampling. Results: Since 2016, telemetry dogs implanted with transmitters and vascular access ports [...]